The Centre has asked states to ensure implementation of its guidelines on home isolation at the field level "in letter and spirit" to effectively contain the spread of the coronavirus, after taking note of instances of laxity. The Ministry of Health and Family Welfare issued revised guidelines for home isolation on May 10 which continue to be effective as on date, an official statement said Friday. According to the guidelines, very mild and pre-symptomatic COVID-19 patients can opt for home isolation, provided the patient has a room for himself/herself with toilet facility and has an adult attendant or caregiver.